Arts District Set on the eastern side of Downtown between Alameda Street, the Los Angeles River, and the 101 and 10 freeways, this area was once the site of California's premier wine vineyards. In more recent decades, it became a vibrant artist enclave. It's one of LA's most authentic and colorful neighborhoods, where coffee shops, general stores and eclectic restaurants line the cozy streets, nestled between adaptive reuse factory conversions that meticulously preserve the appeal of raw industrial spaces enhanced by modern living amenities.